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Probiotics and Other Conditions
Allergies

The increased prevalence of atopic diseases, atopic dermatitis, allergic rhinitis, and asthma has been described as reaching epidemic proportions (Isolauri, 2004). There is abundant evidence to suggest that specific strains of probiotics have an effect on inflammatory processes as demonstrated by the reduction of certain local and systemic immune markers (Isolauri, 2004; Miraglia del Giudice et al., 2004). Impairment of the intestinal mucosal barrier appears to be involved in the pathogenesis of atopic dermatitis (Rosenfeldt et al., 2003). Research suggests that probiotic supplementation may affect the intestinal barrier function in children with this condition. One study performed on rats , explored the effect of daily oral administration of fermented milk containing L. casei or L. casei alone in skin inflammation caused by 2,4-dinitrofluorobenzene, a model of allergic contact dermatitis (Chapat et al., 2004). Another double-blind, placebo-controlled, crossover study, in which two probiotic Lactobacillus strains were given in combination for 6 weeks to 1-to 13-year-old children with atopic dermatitis, explored specifically the effect of this probiotic mix in children with this condition (Rosenfeldt et al., 2003). Probiotics may affect the production of inflammation-producing cells and accessibility of allergens, normalize gut microflora and impact gut barrier function, regulate the secretion of inflammatory mediators and help promote the proper development of the immune system in certain subjects (Isolauri, 2004).
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10.09.05
Probiotics and Pediatrics
Division of Nutrition, Harvard Medical School